The study of oligodendrogliomas has generated great interest in the last fifteen years, because it refers about primar y tumors of the brain, that are quimiosensitive, opposed to the rest of the gliomas, that are characteristicaly quimiorresistent. The rapid advances in technology, allows the study and a better understanding of the chromosomal changes and the deoxyribonucleic acid mutations, that lead to the activation of proto-oncogenes and loss of function of tumor suppresor genes. Some changes, like
deletions in the short arm (p) of the chromosome 1, and the long arm (q) of the chromosome 19, specially when they are
simultaneous, are considered practicaly specific for the diagnosis of oligodendroglioma. This fact has lead us to demostrate, that this tumors are much more frequent, than considered 10 years ago, and that is why the genetic molecular study is an essencial complement to the conventional hystologycal and hystochemichal study of this kind of tumors, that as we know, many times, it not allow us to distinguish from other gliomas. This molecular characterization of gliomas, acquieres great relevance allowing to diagnose a greater number ofoligodendrogliomas orothergliomas with oligodendroglial component that can be treated whith quimiotherapy.
Valencia Z., J. M. ., & Iturra C., P. . (2005). Tratamiento actual de los Oligodendrogliomas: Fundamentos patológicos y de Biología Molecular. Revista Hospital Clínico Universidad De Chile, 16(3), pp. 211–20. https://doi.org/10.5354/2735-7996.2005.78671
